Pedigree and Phylogenetic Tree Examples

Two childrens of a non consangenous marrioage one is female and other one is male

A carrier mother and unaffected father have an affected son, a carrier daughter, an unaffected son, and an unaffected daughter, shown across two generations.

An autosomal dominant pedigree across three generations. An affected father and unaffected mother have an affected daughter and unaffected son; the affected daughter has one affected and one unaffected child with an unaffected partner.

Mr. Antonio Rossi (26 years old), healthy (has had intestinal polyps for 1 year) Mother: Francesca Rossi (52 years old), healthy Father: Marco Rossi (54 years old), healthy—has had over 100 intestinal polyps for 28 years, but no cancer diagnosis Sister: Chiara Rossi (33 years old), healthy Maternal side: no information available, but no history of cancer Paternal side: Aunt 1: Elena Verdi (46 years old), healthy; married to Carlo Verdi (48 years old), healthy Children: Franco Verdi (18 years old), healthy Federica Verdi (15 years old), healthy Alessandro Verdi (15 years old), healthy Paolo Verdi (12 years old), healthy Aunt 2: Giulia Bianchi (51 years old), healthy—married to Enrico Bianchi (53 years old), healthy Children: Mia Bianchi (28 years old), healthy Enrico Bianchi Jr. (24 years old), healthy Giulia Bianchi Jr. (20 years old), healthy Uncle: Paolo Rossi (deceased at age 41) developed colon cancer at age 38 following an ileus Was married to Laura Rossi Children: Raffaela Rossi (age 29) had several colon polyps removed after noticing blood in her stool Emilio Rossi (age 22) healthy Grandparents: Grandmother: Maria Rossi (78 years old), healthy Grandfather: Giovanni Rossi (died at age 48 from colon cancer) – was diagnosed with cancer at age 42 Great-uncle 1: Alberto Marzi (92 years old), healthy Great-uncle 2: Lorenzo Rossi (died at age 53 from rectal cancer) – developed several colorectal polyps in his early 30s Great-aunt 1: Vittoria Regiano (81 years old), healthy Great Translated with DeepL.com (free version)

Description de l’arbre généalogique (Document 1) Génération I : - L’individu I₁ est une femme atteinte de la maladie. - L’individu I₂ est un homme sain. Génération II : - Les individus II₂ et II₃ sont des hommes atteints. - L’individu II₄ est une femme saine, mariée à l’individu II₃. Génération III : - Descendance de II₂ : une fille atteinte (III₁) et deux garçons sains (III₂ et III₃). - Descendance du couple II₃ × II₄ : une fille atteinte (III₄) et deux garçons sains (III₅ et III₆).

Description de l'arbre généalogique (Document 1)Génération I :La femme $\text{I}_1$ est atteinte de la maladie. L'homme $\text{I}_2$ est sain. Génération II :Les individus $\text{II}_2$ et $\text{II}_3$ sont des hommes atteints. L'individu $\text{II}_4$ est une femme saine mariée à l'homme $\text{II}_3$. Génération III :Descendance de $\text{II}_2$ : une fille atteinte ($\text{III}_1$) et deux garçons sains ($\text{III}_2$, $\text{III}_3$). Descendance du couple $\text{II}_3 \times \text{II}_4$ : une fille atteinte ($\text{III}_4$) et deux garçons sains ($\text{III}_5$, $\text{III}_6$